Journal of Law, Medicine and Ethics 36 (3):567-576 (2008)

Authors
Ariella Binik
McMaster University
Abstract
This article reviews four areas of pediatric research in which we have identified questionable levels of allowable risk, exceeding those foreseen by the Commission. They are the following: the categorization of increasingly risky interventions as minimal risk in a variety of protocols; the increasing number of applications for federal panel review of research not otherwise approvable because of higher projected risk levels; research on asymptomatic at risk children; and the inclusion of children and adolescents in placebo-controlled trials for participants of all ages without performing subgroup analysis. While embracing the imperative to include children in research is an encouraging step towards providing the pediatric population with effective medical care and finally eradicating the therapeutic orphan, we must ensure that this research does not become overly permissive
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DOI 10.1111/j.1748-720X.2008.305.x
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References found in this work BETA

Minimal Risk as an International Ethical Standard in Research.Loretta M. Kopelman - 2004 - Journal of Medicine and Philosophy 29 (3):351 – 378.
Proxy Consent in the Experimentation Situation.Richard A. Mc Cormick - 1974 - Perspectives in Biology and Medicine 18 (1):2-20.

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