Ethical Issues in the Development and Testing of a Preventive Hiv Vaccine.

Dissertation, Georgetown University (1993)

This dissertation explores the ethics of human subjects research with particular attention to how clinical research on vaccines differs from research on therapies. The major differences are rooted in the fact that the benefits of vaccines and vaccine research accrue to the community to which vaccines belong by inducing herd immunity and thereby protecting both vaccinated and unvaccinated individuals. Therapeutics have no corresponding benefit to the community, the primary beneficiary is the individual. The ethical justification for conducting vaccine research in a given community therefore should include an evaluation of the risks and benefits to the community as well as to involved individuals. Respect for individuals extends to respect for communities and for individuals as members of communities. A three way partnership between investigators, the community, and the community members is suggested as an ethical foundation for vaccine research. ;This model is then applied to the particular and complex case of testing a preventive HIV vaccine. HIV is an unique virus which continues to cause extraordinary devastation worldwide. The characteristics of HIV, its transmission and epidemiology, along with unprecedented scientific possibilities present a formidable challenge to the development and testing of an HIV vaccine. Using the community model, specific suggestions are made for the ethical conduct of clinical efficacy trials of HIV preventive vaccines
Keywords No keywords specified (fix it)
Categories (categorize this paper)
Edit this record
Mark as duplicate
Export citation
Find it on Scholar
Request removal from index
Revision history

Download options

PhilArchive copy

Upload a copy of this paper     Check publisher's policy     Papers currently archived: 71,316
External links

Setup an account with your affiliations in order to access resources via your University's proxy server
Configure custom proxy (use this if your affiliation does not provide a proxy)
Through your library

References found in this work BETA

No references found.

Add more references

Citations of this work BETA

No citations found.

Add more citations

Similar books and articles

Hiv Preventive Vaccine Research: Selected Ethical Issues.Christine Grady - 1994 - Journal of Medicine and Philosophy 19 (6):595-612.
Ethically Compromised Vaccines in Australia.Kerri Anne Brussen - 2012 - Chisholm Health Ethics Bulletin 17 (3):1.
HIV Vaccine Trial Participation in South Africa - an Ethical Assessment.Keymanthri Moodley - 2002 - Journal of Medicine and Philosophy 27 (2):197 – 215.
Strategies of Research For a Vaccine Against AIDS.Max Essex - 1995 - History and Philosophy of the Life Sciences 17 (1):141 - 149.


Added to PP index

Total views

Recent downloads (6 months)

How can I increase my downloads?


Sorry, there are not enough data points to plot this chart.

My notes