Persistent pain: Trim the branches or fell the tree?

Behavioral and Brain Sciences 20 (3):449-451 (1997)

In patients with pain characterized by a painful focus and allodynia, the painful symptoms arise from altered central processing that is initiated and subsequently maintained by persistent input from nociceptive afferents. Treatments directed at this normal consequence of persistent input are inherently limited. The most efficacious treatments will target the pathology, the various sources of ongoing nociceptor input. [blumberg et al.; coderre & katz; dickenson]
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DOI 10.1017/s0140525x97331495
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