Relative Versus Absolute Standards for Everyday Risk in Adolescent HIV Prevention Trials: Expanding the Debate

American Journal of Bioethics 11 (6):5 - 13 (2011)

Authors
Jeremy Snyder
Simon Fraser University
Abstract
The concept of minimal risk has been used to regulate and limit participation by adolescents in clinical trials. It can be understood as setting an absolute standard of what risks are considered minimal or it can be interpreted as relative to the actual risks faced by members of the host community for the trial. While commentators have almost universally opposed a relative interpretation of the environmental risks faced by potential adolescent trial participants, we argue that the ethical concerns against the relative standard may not be as convincing as these commentators believe. Our aim is to present the case for a relative standard of environmental risk in order to open a debate on this subject. We conclude by discussing how a relative standard of environmental risk could be defended in the specific case of an HIV vaccine trial among adolescents in South Africa
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DOI 10.1080/15265161.2011.568576
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References found in this work BETA

Minimal Risk as an International Ethical Standard in Research.Loretta M. Kopelman - 2004 - Journal of Medicine and Philosophy 29 (3):351 – 378.
The Patient as Person.Paul Ramsey - 1970 - New Haven: Yale University Press.
Children as Research Subjects: A Dilemma.Loretta M. Kopelman - 2000 - Journal of Medicine and Philosophy 25 (6):723-744.
Risk Standards for Pediatric Research: Rethinking the Grimes Ruling.David Wendler - 2004 - Kennedy Institute of Ethics Journal 14 (2):187-198.

View all 14 references / Add more references

Citations of this work BETA

The Dangers of Using a Relative Risk Standard for Minimal Risk.Seema Shah - 2011 - American Journal of Bioethics 11 (6):22 - 23.
Reopening Old Divisions.David B. Resnik - 2011 - American Journal of Bioethics 11 (6):19 - 21.
Minimal Risk Remains an Open Question.Ariella Binik, Charles Weijer & Mark Sheehan - 2011 - American Journal of Bioethics 11 (6):25 - 27.

View all 12 citations / Add more citations

Similar books and articles

HIV Vaccine Trial Participation in South Africa - an Ethical Assessment.Keymanthri Moodley - 2002 - Journal of Medicine and Philosophy 27 (2):197 – 215.
Valuing Risk: The Ethical Review of Clinical Trial Safety.Jonathan Kimmelman - 2004 - Kennedy Institute of Ethics Journal 14 (4):369-393.
Risk Standards for Pediatric Research: Rethinking The.David Wendler - 2004 - Kennedy Institute of Ethics Journal 14 (2):187-198.

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