Network analyses in systems biology: new strategies for dealing with biological complexity

Synthese 195 (4):1751-1777 (2018)
  Copy   BIBTEX

Abstract

The increasing application of network models to interpret biological systems raises a number of important methodological and epistemological questions. What novel insights can network analysis provide in biology? Are network approaches an extension of or in conflict with mechanistic research strategies? When and how can network and mechanistic approaches interact in productive ways? In this paper we address these questions by focusing on how biological networks are represented and analyzed in a diverse class of case studies. Our examples span from the investigation of organizational properties of biological networks using tools from graph theory to the application of dynamical systems theory to understand the behavior of complex biological systems. We show how network approaches support and extend traditional mechanistic strategies but also offer novel strategies for dealing with biological complexity.

Links

PhilArchive



    Upload a copy of this work     Papers currently archived: 76,419

External links

Setup an account with your affiliations in order to access resources via your University's proxy server

Through your library

Similar books and articles

Mechanists Must be Holists Too! Perspectives from Circadian Biology.William Bechtel - 2016 - Journal of the History of Biology 49 (4):705-731.
Systems biology and the integration of mechanistic explanation and mathematical explanation.Ingo Brigandt - 2013 - Studies in History and Philosophy of Biological and Biomedical Sciences 44 (4):477-492.

Analytics

Added to PP
2017-01-20

Downloads
69 (#176,155)

6 months
2 (#300,644)

Historical graph of downloads
How can I increase my downloads?

Author Profiles

Ingo Brigandt
University of Alberta
Sara-Lee Green
Lund University
2 more

References found in this work

Thinking about mechanisms.Peter Machamer, Lindley Darden & Carl F. Craver - 2000 - Philosophy of Science 67 (1):1-25.
Explanation: a mechanist alternative.William Bechtel & Adele Abrahamsen - 2005 - Studies in History and Philosophy of Biological and Biomedical Sciences 36 (2):421-441.
Making Things Happen. A Theory of Causal Explanation.Michael Strevens - 2007 - Philosophy and Phenomenological Research 74 (1):233-249.

View all 14 references / Add more references