Theoretical Medicine and Bioethics 27 (6):499-521 (2006)

Authors
Karola Stotz
Last affiliation: Macquarie University
Paul Edmund Griffiths
University of Sydney
Abstract
We outline three very different concepts of the gene—instrumental, nominal, and postgenomic. The instrumental gene has a critical role in the construction and interpretation of experiments in which the relationship between genotype and phenotype is explored via hybridization between organisms or directly between nucleic acid molecules. It also plays an important theoretical role in the foundations of disciplines such as quantitative genetics and population genetics. The nominal gene is a critical practical tool, allowing stable communication between bioscientists in a wide range of fields grounded in well-defined sequences of nucleotides, but this concept does not embody major theoretical insights into genome structure or function. The post-genomic gene embodies the continuing project of understanding how genome structure supports genome function, but with a deflationary picture of the gene as a structural unit. This final concept of the gene poses a significant challenge to conventional assumptions about the relationship between genome structure and function, and between genotype and phenotype.
Keywords Gene definition  gene concepts  postgenomics  history of genetics  conceptual change
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DOI 10.1007/s11017-006-9020-y
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References found in this work BETA

The Structure of Scientific Revolutions.Thomas Samuel Kuhn - 1962 - Chicago: University of Chicago Press.
Philosophy of Experimental Biology.Marcel Weber - 2004 - Cambridge University Press.
What Genes Can't Do.Lenny Moss - 2002 - MIT Press.
Philosophy of Experimental Biology.Jacob Stegenga - 2009 - Erkenntnis 71 (3):431-436.

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Citations of this work BETA

What is an Organism? An Immunological Answer.Thomas Pradeu - 2010 - History and Philosophy of the Life Sciences 32 (2-3):247-267.
Revising, Correcting, and Transferring Genes.Bryan Cwik - 2020 - American Journal of Bioethics 20 (8):7-18.
The Evolutionary Gene and the Extended Evolutionary Synthesis.Qiaoying Lu & Pierrick Bourrat - 2017 - British Journal for the Philosophy of Science 69 (3):775-800.
Rethinking the Problem of Cognition.Mikio Akagi - 2018 - Synthese 195 (8):3547-3570.

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