Genes in the postgenomic era

Theoretical Medicine and Bioethics 27 (6):499-521 (2006)
Abstract
We outline three very different concepts of the gene—instrumental, nominal, and postgenomic. The instrumental gene has a critical role in the construction and interpretation of experiments in which the relationship between genotype and phenotype is explored via hybridization between organisms or directly between nucleic acid molecules. It also plays an important theoretical role in the foundations of disciplines such as quantitative genetics and population genetics. The nominal gene is a critical practical tool, allowing stable communication between bioscientists in a wide range of fields grounded in well-defined sequences of nucleotides, but this concept does not embody major theoretical insights into genome structure or function. The post-genomic gene embodies the continuing project of understanding how genome structure supports genome function, but with a deflationary picture of the gene as a structural unit. This final concept of the gene poses a significant challenge to conventional assumptions about the relationship between genome structure and function, and between genotype and phenotype.
Keywords Gene definition  gene concepts  postgenomics  history of genetics  conceptual change
Categories (categorize this paper)
DOI 10.1007/s11017-006-9020-y
Options
 Save to my reading list
Follow the author(s)
Edit this record
My bibliography
Export citation
Find it on Scholar
Mark as duplicate
Request removal from index
Revision history
Download options
Our Archive


Upload a copy of this paper     Check publisher's policy     Papers currently archived: 30,133
Through your library
References found in this work BETA
The Structure of Scientific Revolutions.Thomas S. Kuhn - 1962 - University of Chicago Press.
Genes Made Molecular.C. Kenneth Waters - 1994 - Philosophy of Science 61 (2):163-185.
A History of Molecular Biology.Michel Morange & Matthew Cobb - 1999 - Journal of the History of Biology 32 (3):568-570.

View all 12 references / Add more references

Citations of this work BETA
Experimental Philosophy of Science.Paul E. Griffiths & Karola Stotz - 2008 - Philosophy Compass 3 (3):507–521.
Experimental Philosophy of Biology: Notes From the Field.Karola Stotz - 2009 - Studies in History and Philosophy of Science Part A 40 (2):233-237.
NATURE's DARK DOMAIN: AN ARGUMENT FOR A NATURALIZED PHENOMENOLOGY.David Roden - 2013 - Royal Institute of Philosophy Supplement 72 (1):169-88.
Experimental Philosophy of Economics.Michiru Nagatsu - 2013 - Economics and Philosophy 29 (2):263-76.

View all 21 citations / Add more citations

Similar books and articles
Added to PP index
2009-01-28

Total downloads
185 ( #25,015 of 2,191,816 )

Recent downloads (6 months)
1 ( #290,783 of 2,191,816 )

How can I increase my downloads?

Monthly downloads
My notes
Sign in to use this feature