Bioessays 40 (9):1800028 (2018)

Organogenesis and metamorphosis require the intricate orchestration of multiple types of cellular interactions and signaling pathways. Glutamate (Glu) is an excitatory extracellular signaling molecule in the nervous system, while Ca2+ is a major intracellular signaling molecule. The first Glu receptors to be cloned are Ca2+‐permeable receptors in mammalian brains. Although recent studies have focused on Glu signaling in synaptic mechanisms of the mammalian central nervous system, it is unclear how this signaling functions in development. Our recent article demonstrated that Ca2+‐permeable AMPA‐type Glu receptors (GluAs) are essential for formation of a photosensitive organ, development of some neurons, and metamorphosis, including tail absorption and body axis rotation, in ascidian embryos. Based on findings in these embryos and mammalian brains, we formed several hypotheses regarding the evolution of GluAs, the non‐synaptic function of Glu, the origin of GluA‐positive neurons, and the neuronal network that controls metamorphosis in ascidians.
Keywords AMPA‐type receptor  ascidian development  calcium permeability  evolution  glutamate receptor  metamorphosis  organ formation
Categories (categorize this paper)
DOI 10.1002/bies.201800028
Edit this record
Mark as duplicate
Export citation
Find it on Scholar
Request removal from index
Revision history

Download options

PhilArchive copy

Upload a copy of this paper     Check publisher's policy     Papers currently archived: 52,823
Through your library

References found in this work BETA

Add more references

Citations of this work BETA

No citations found.

Add more citations

Similar books and articles

Embryology and Evolution 1920-1960: Worlds Apart?Ron Amundson - 2000 - History and Philosophy of the Life Sciences 22 (3):335 - 352.
Development, Evolution, and Adaptation.Kim Sterelny - 2000 - Philosophy of Science 67 (3):387.


Added to PP index

Total views
23 ( #430,857 of 2,342,653 )

Recent downloads (6 months)
1 ( #515,081 of 2,342,653 )

How can I increase my downloads?


My notes