Bioessays 38 (1):109-117 (2016)

Abstract
Remnants of ancient retroviral infections during evolution litter all mammalian genomes. In modern humans, such endogenous retroviral (ERV) sequences comprise at least 8% of the genome. While ERVs and other types of transposable elements undoubtedly contribute to the genomic “junk yard”, functions for some ERV sequences have been demonstrated, with growing evidence that ERVs can be important players in gene regulatory processes. Here we focus on one particular large family of human ERVs, termed HERVH, which several recent studies suggest has a key regulatory role in human pluripotent stem cells. Remarkably, this is not the first instance of an ERV controlling pluripotency. We speculate as to why this convergent evolution might have come about, suggesting that it may reflect selection on the virus to extend the time available for transposition. Alternatively it may reflect serendipity alone.
Keywords No keywords specified (fix it)
Categories (categorize this paper)
DOI 10.1002/bies.201500096
Options
Edit this record
Mark as duplicate
Export citation
Find it on Scholar
Request removal from index
Revision history

Download options

PhilArchive copy


Upload a copy of this paper     Check publisher's policy     Papers currently archived: 59,827
External links

Setup an account with your affiliations in order to access resources via your University's proxy server
Configure custom proxy (use this if your affiliation does not provide a proxy)
Through your library

References found in this work BETA

No references found.

Add more references

Citations of this work BETA

Add more citations

Similar books and articles

Serendipity: Fortune and the Prepared Mind.Mark de Rond & Iain Morley (eds.) - 2010 - Cambridge University Press.
Understanding Humans: Serendipity and Anthropology‖.Richard Leakey - 2010 - In Mark de Rond & Iain Morley (eds.), Serendipity: Fortune and the Prepared Mind. Cambridge University Press. pp. 22--27.
6 Serendipity in Physics.Richard Friend - 2010 - In Mark de Rond & Iain Morley (eds.), Serendipity: Fortune and the Prepared Mind. Cambridge University Press. pp. 22--91.
1 The Stratigraphy of Serendipity.Susan E. Alcock - 2010 - In Mark de Rond & Iain Morley (eds.), Serendipity: Fortune and the Prepared Mind. Cambridge University Press. pp. 22--11.
5 Serendipity in Astronomy.Andrew C. Fabian - 2010 - In Mark de Rond & Iain Morley (eds.), Serendipity: Fortune and the Prepared Mind. Cambridge University Press. pp. 22--73.

Analytics

Added to PP index
2016-02-04

Total views
6 ( #1,083,403 of 2,432,722 )

Recent downloads (6 months)
1 ( #464,418 of 2,432,722 )

How can I increase my downloads?

Downloads

My notes