Incompetent Persons as Research Subjects and the Ethics of Minimal Risk


Abstract
The voluntary and informed consent of subjects has been the central focus of concern in research reviews, overshadowing the importance of all other considerations. The Nuremberg Code, with its rights-based protection of the subject's autonomy above all else, made it difficult to justify research with no intended benefit when subjects are incompetent to make a valid informed choice to participate. Subsequent codes providing for research with incompetent subjects followed the lead of Nuremberg, substituting the informed authorization of a proxy for the informed consent of the subject
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DOI 10.1017/s0963180100007179
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References found in this work BETA

Deciding for Others.Gerald Dworkin, Allen E. Buchanan & Dan W. Brock - 1991 - Philosophical Quarterly 41 (162):118.
The Many Faces of Competency.James F. Drane - 1985 - Hastings Center Report 15 (2):17-21.
Proxy Consent in the Experimentation Situation.Richard A. Mc Cormick - 1974 - Perspectives in Biology and Medicine 18 (1):2-20.

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Citations of this work BETA

Rethinking Risk in Pediatric Research.Kathleen Cranley Glass & Ariella Binik - 2008 - Journal of Law, Medicine and Ethics 36 (3):567-576.
Decisionally Impaired Persons in Research: Refining the Proposed Refinements.Evan G. DeRenzo - 1997 - Journal of Law, Medicine and Ethics 25 (2-3):139-149.
Decisionally Impaired Persons in Research: Refining the Proposed Refinements.Evan G. DeRenzo - 1997 - Journal of Law, Medicine and Ethics 25 (2-3):139-149.

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