An evolutionary framework for mental disorders: Integrating adaptationist and evolutionary genetic models

Behavioral and Brain Sciences 29 (4):429-441 (2006)
Abstract
This response (a) integrates non-equilibrium evolutionary genetic models, such as coevolutionary arms-races and recent selective sweeps, into a framework for understanding common, harmful, heritable mental disorders; (b) discusses the forms of ancestral neutrality or balancing selection that may explain some portion of mental disorder risk; and (c) emphasizes that normally functioning psychological adaptations work against a backdrop of mutational and environmental noise. (Published Online November 9 2006).
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DOI 10.1017/S0140525X06459094
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