Views of the process and content of ethical reviews of hiv vaccine trials among members of us institutional review boards and south african research ethics committees

Developing World Bioethics 8 (3):207-218 (2008)

Abstract
ABSTRACTGiven the ethical controversies concerning HIV vaccine trials , we aimed to understand through an exploratory study how members of institutional review boards in the United States and research ethics committees in South Africa view issues concerning the process and content of reviews of these studies. We mailed packets of 20 questionnaires to 12 US IRB chairs and administrators and seven REC chairs to distribute to their members. We received 113 questionnaires . In both countries, members tended to be white males with advanced academic degrees. Compared to the US, SA members called for ‘major changes’ in HVT protocols more frequently , and were less likely to think that HVT participants understood risks and benefits or informed consent forms . In both countries, members were divided on several critical issues , but agreed that they needed more training. Of the SA respondents, 40% reported that they were ‘self‐taught’ in ethics. This study, the first we know of to offer quantitative data comparing US vs. non‐US IRBs/RECs, thus suggests key similarities and differences , along with needs for education. These initial exploratory data in this area have important implications for IRBs, RECs, policy‐makers and scholars concerning future practice, training, policy, and investigations in research ethics, and prevention and treatment of HIV and other diseases in the developing world and elsewhere
Keywords info:mesh/Health Personnel  info:mesh/United States  info:mesh/Research Personnel  info:mesh/Aged  info:mesh/Ethnic Groups  info:mesh/Middle Aged  info:mesh/Clinical Trials as Topic  info:mesh/South Africa  Humans   HIV Infections   AIDS Vaccines   Questionnaires   Research Design   Ethical Review   Ethics Committees, Research   Ethics, Research   Adult   Aged   Middle Aged   Health Personnel   Research Personnel   Ethnic Groups   South Africa   United States   Female   Male   Clinical Trials as Topic  info:mesh/Ethical Review  info:mesh/Research Design  info:mesh/Humans  info:mesh/Ethics Committees, Research  info:mesh/Adult  info:mesh/AIDS Vaccines  info:mesh/HIV Infections  info:mesh/Questionnaires  info:mesh/Male  info:mesh/Female  info:mesh/Ethics, Research
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DOI 10.1111/j.1471-8847.2007.00189.x
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A Defense of the Common Morality.Tom L. Beauchamp - 2003 - Kennedy Institute of Ethics Journal 13 (3):259-274.

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