The role of basic science in evidence-based medicine

Biology and Philosophy 26 (1):81-98 (2011)
Abstract
Proponents of Evidence-based medicine (EBM) do not provide a clear role for basic science in therapeutic decision making. Of what they do say about basic science, most of it is negative. Basic science resides on the lower tiers of EBM's hierarchy of evidence. Therapeutic decisions, according to proponents of EBM, should be informed by evidence from randomised studies (and systematic reviews of randomised studies) rather than basic science. A framework of models explicates the links between the mechanisms of basic science, experimental inquiry, and observed data. Relying on the framework of models I show that basic science often plays a role not only in specifying experiments, but also analysing and interpreting the data that is provided. Further, and contradicting what is implied in EBM's hierarchy of evidence, appeals to basic science are often required to apply clinical research to therapeutic questions. © 2010 Springer Science+Business Media B.V
Keywords Evidence-based medicine   Epidemiology   Basic medical science   Clinical decisions   Randomised controlled trials
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Reprint years 2011
DOI 10.1007/s10539-010-9231-5
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References found in this work BETA
Thinking About Mechanisms.Peter K. Machamer, Lindley Darden & Carl F. Craver - 2000 - Philosophy of Science 67 (1):1-25.
Error and the Growth of Experimental Knowledge.Deborah G. Mayo - 1996 - International Studies in the Philosophy of Science 15 (1):455-459.

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Citations of this work BETA
Mechanisms: What Are They Evidence for in Evidence-Based Medicine.Holly Andersen - 2012 - Journal of Evaluation in Clinical Practice 18 (5):992-999.
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Causal Models and Evidential Pluralism in Econometrics.Alessio Moneta & Federica Russo - 2014 - Journal of Economic Methodology 21 (1):54-76.

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