CRISPR Gene-Therapy: A Critical Review of Ethical Concerns and a Proposal for Public Decision-Making

Abstract

CRISPR is currently viewed as the central tool for future gene therapy. Yet, many prominent scientists and bioethicists have expressed ethical concerns around CRISPR gene therapy. This paper provides a critical review of concerns about CRISPR gene therapy as expressed in the mainstream academic literature, paired with replies also generally found in that literature. The expressed concerns can be categorised into three types depending on whether they stress risk/benefit ratio, autonomy and informed consent, or concerns related to various aspects of justice. In the reviewed literature, we found no intrinsic objections to CRISPR gene therapy, even though many such objections were present in discussions of gene editing in the 1990s. The paper then proposes a brief outline for a practically applicable moral framework for public decision-making about CRISPR gene therapy and suggests how such a framework might be supported. We also suggest that this framework should govern public engagement about CRISPR gene therapy in order to reduce the risk that we make decisions about CRISPR gene therapy based on misperceptions, inflated views of risk, or unreasonable moral or religious views.

Links

PhilArchive



    Upload a copy of this work     Papers currently archived: 94,549

External links

Setup an account with your affiliations in order to access resources via your University's proxy server

Through your library

  • Only published works are available at libraries.

Similar books and articles

Better Humans and evolutionary nudge.Ann Boyd - 2017 - Eubios Journal of Asian and International Bioethics 27 (4):116-120.
Nurturing or Purifying the Human Genome: Promises and Pitfalls of CRISPR Germline Editing.Evelyne Shuster - 2015 - Ethics in Biology, Engineering and Medicine 6 (3-4):299-304.
Altered Inheritance: Crispr and the Ethics of Human Genome Editing.Françoise Baylis - 2019 - Cambridge, Massachusetts: Harvard University Press.

Analytics

Added to PP
2022-07-02

Downloads
55 (#287,157)

6 months
16 (#219,377)

Historical graph of downloads
How can I increase my downloads?

Author's Profile

Klemens Kappel
University of Copenhagen

Citations of this work

No citations found.

Add more citations