Journal of Medicine and Philosophy 16 (6):621-639 (1991)

This essay examines the arguments for and against working towards the objective of human germ line engineering for medical purposes. Germ line changes which result as a secondary consequence of other well designed and ethically acceptable manipulations of somatic cells to cure an otherwise fatal disease can be seen as acceptable. More serious objections apply to intentional germ line interventions because of the unacceptability of using a person solely as a vehicle for creating uncertain genetic change in his descendants. It is also morally unacceptable to use the promise of future benefit to experiment on fetuses or embryos when other more effective technologies exist to help parents have healthy children. Using new genetic technologies to select desirable genotypes among gametes is less problematic and affords a promising new technique for avoiding intergenerational harms. Keywords: embryo research, germ line manipulation, intergenerational ethics, secondary germ line effects CiteULike Connotea What's this?
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DOI 10.1093/jmp/16.6.621
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Trust in Science: CRISPR–Cas9 and the Ban on Human Germline Editing.Stephan Guttinger - 2018 - Science and Engineering Ethics 24 (4):1077-1096.
Germ-Line Genetic Enhancement and Rawlsian Primary Goods.Fritz Allhoff - 2005 - Kennedy Institute of Ethics Journal 15 (1):39-56.
Germ-Line Enhancement of Humans and Nonhumans.J. Robert Loftis - 2005 - Kennedy Institute of Ethics Journal 15 (1):57-76.
Seeking Perfection: A Kantian Look at Human Genetic Engineering.Martin Gunderson - 2007 - Theoretical Medicine and Bioethics 28 (2):87-102.
Altering Humans—The Case For and Against Human Gene Therapy.Nils Holtug - 1997 - Cambridge Quarterly of Healthcare Ethics 6 (2):157-174.

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