Strategies in the interfield discovery of the mechanism of protein synthesis

Abstract
In the 1950s and 1960s, an interfield interaction between molecular biologists and biochemists integrated important discoveries about the mechanism of protein synthesis. This extended discovery episode reveals two general reasoning strategies for eliminating gaps in descriptions of the productive continuity of mechanisms: schema instantiation and forward chaining/backtracking. Schema instantiation involves filling roles in an overall framework for the mechanism. Forward chaining and backtracking eliminate gaps using knowledge about types of entities and their activities. Attention to mechanisms highlights salient features of this historical episode while providing general reasoning strategies for mechanism discovery
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DOI 10.1016/S1369-8486(01)00021-8
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References found in this work BETA
Thinking About Mechanisms.Peter K. Machamer, Lindley Darden & Carl F. Craver - 2000 - Philosophy of Science 67 (1):1-25.
Interfield Theories.Lindley Darden & Nancy Maull - 1977 - Philosophy of Science 44 (1):43-64.
Discovering Mechanisms in Neurobiology: The Case of Spatial Memory.Carl F. Craver & Lindley Darden - 2001 - In P.K. Machamer, Rick Grush & Peter McLaughlin (eds.), Theory and Method in Neuroscience. Pittsburgh: University of Pitt Press. pp. 112--137.
A History of Molecular Biology.Michel Morange & Matthew Cobb - 1999 - Journal of the History of Biology 32 (3):568-570.

View all 15 references / Add more references

Citations of this work BETA
Explanation: A Mechanist Alternative.William Bechtel - 2005 - Studies in History and Philosophy of Biol and Biomed Sci 36 (2):421--441.
Abstraction and the Organization of Mechanisms.Arnon Levy & William Bechtel - 2013 - Philosophy of Science 80 (2):241-261.
Mechanism and Biological Explanation.William Bechtel - 2011 - Philosophy of Science 78 (4):533-557.
Thinking About Evolutionary Mechanisms: Natural Selection.Robert A. Skipper & Roberta L. Millstein - 2005 - Studies in History and Philosophy of Biological and Biomedical Sciences 36 (2):327-347.

View all 33 citations / Add more citations

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Discovering Mechanisms in Neurobiology: The Case of Spatial Memory.Carl F. Craver & Lindley Darden - 2001 - In P.K. Machamer, Rick Grush & Peter McLaughlin (eds.), Theory and Method in Neuroscience. Pittsburgh: University of Pitt Press. pp. 112--137.
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