1 H magnetic resonance spectroscopy of normal appearing white matter in primary progressive multiple sclerosis

Journal of Neurology 246 (11) (1999)

Abstract
Recent magnetic resonance imaging and pathological studies have indicated that axonal loss is a major contributor to disease progression in multiple sclerosis. 1 H magnetic resonance spectroscopy, through measurement of N -acetyl aspartate, a neuronal marker, provides a unique tool to investigate this. Patients with primary progressive multiple sclerosis have few lesions on conventional MRI, suggesting that changes in normal appearing white matter, such as axonal loss, may be particularly relevant to disease progression in this group. To test this hypothesis NAWM was studied with MRS, measuring the concentration of N -acetyl derived groups. Single-voxel MRS using a water-suppressed PRESS sequence was carried out in 24 patients with primary progressive multiple sclerosis and in 16 age-matched controls. Ratios of metabolite to creatine concentration were calculated in all subjects, and absolute concentrations were measured in 18 patients and all controls. NA/Cr was significantly lower in NAWM in patients than in controls, as was the absolute concentration of NA. There was no significant difference in the absolute concentration of creatine between the groups. This study supports the hypothesis that axonal loss occurs in NAWM in primary progressive multiple sclerosis and may well be a mechanism for disease progression in this group
Keywords No keywords specified (fix it)
Categories (categorize this paper)
Options
Edit this record
Mark as duplicate
Export citation
Find it on Scholar
Request removal from index
Revision history

Download options

Our Archive


Upload a copy of this paper     Check publisher's policy     Papers currently archived: 42,938
External links

Setup an account with your affiliations in order to access resources via your University's proxy server
Configure custom proxy (use this if your affiliation does not provide a proxy)
Through your library

References found in this work BETA

No references found.

Add more references

Citations of this work BETA

No citations found.

Add more citations

Similar books and articles

The Contemporary Significance of Confucianism.Tang Yijie & Yan Xin - 2008 - Frontiers of Philosophy in China 3 (4):477-501.
How Bad Is Rape?H. E. Baber - 1987 - Hypatia 2 (2):125-138.
The Hiddenness Argument Revisited.J. L. Schellenberg - 2005 - Religious Studies 41 (3):287-303.
Shifting Frames: From Divided to Distributed Psychologies of Scientific Agents.Peter J. Taylor - 1994 - PSA: Proceedings of the Biennial Meeting of the Philosophy of Science Association 1994:304-310.

Analytics

Added to PP index
2010-04-17

Total views
29 ( #291,589 of 2,259,260 )

Recent downloads (6 months)
2 ( #670,804 of 2,259,260 )

How can I increase my downloads?

Downloads

My notes

Sign in to use this feature