The evolution of failure: explaining cancer as an evolutionary process

Biology and Philosophy 31 (1):39-57 (2016)
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Abstract

One of the major developments in cancer research in recent years has been the construction of models that treat cancer as a cellular population subject to natural selection. We expand on this idea, drawing upon multilevel selection theory. Cancer is best understood in our view from a multilevel perspective, as both a by-product of selection at other levels of organization, and as subject to selection at several levels of organization. Cancer is a by-product in two senses. First, cancer cells co-opt signaling pathways that are otherwise adaptive at the organismic level. Second, cancer is also a by-product of features distinctive to the metazoan lineage: cellular plasticity and modularity. Applying the multilevel perspective in this way permits one to explain transitions in complexity and individuality in cancer progression. Our argument is a reply to Germain’s scepticism towards the explanatory relevance of natural selection for cancer. The extent to which cancer fulfills the conditions for being a paradigmatic Darwinian population depends on the scale of analysis, and the details of the purported selective scenario. Taking a multilevel perspective clarifies some of the complexities surrounding how to best understand the relevance of evolutionary thinking in cancer progression

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Author Profiles

Anya Plutynski
Washington University in St. Louis
Christopher Lean
University of Sydney

Citations of this work

Against Organizational Functions.Justin Garson - 2017 - Philosophy of Science 84 (5):1093-1103.
Truth or Spin? Disease Definition in Cancer Screening.Lynette Reid - 2017 - Journal of Medicine and Philosophy 42 (4):385-404.
Biological functions and natural selection: a reappraisal.Marc Artiga - 2021 - European Journal for Philosophy of Science 11 (2):1-22.

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