Clinical trialist perspectives on the ethics of adaptive clinical trials: a mixed-methods analysis

BMC Medical Ethics 16 (1):27 (2015)

Abstract
In an adaptive clinical trial , key trial characteristics may be altered during the course of the trial according to predefined rules in response to information that accumulates within the trial itself. In addition to having distinguishing scientific features, adaptive trials also may involve ethical considerations that differ from more traditional randomized trials. Better understanding of clinical trial experts’ views about the ethical aspects of adaptive designs could assist those planning ACTs. Our aim was to elucidate the opinions of clinical trial experts regarding their beliefs about ethical aspects of ACTs
Keywords Adaptive clinical trials  Mixed methods  Ethics  Visual analogue scale  Clinical trials  Qualitative research  Emergency medicine  Neurological emergency  Informed consent  Equipoise
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DOI 10.1186/s12910-015-0022-z
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