An Ethical Framework for Research Using Genetic Ancestry

Perspectives in Biology and Medicine 66 (2):225-248 (2023)
  Copy   BIBTEX


ABSTRACT:A wide range of research uses patterns of genetic variation to infer genetic similarity between individuals, typically referred to as genetic ancestry. This research includes inference of human demographic history, understanding the genetic architecture of traits, and predicting disease risk. Researchers are not just structuring an intellectual inquiry when using genetic ancestry, they are also creating analytical frameworks with broader societal ramifications. This essay presents an ethics framework in the spirit of virtue ethics for these researchers: rather than focus on rule following, the framework is designed to build researchers’ capacities to react to the ethical dimensions of their work. The authors identify one overarching principle of intellectual freedom and responsibility, noting that freedom in all its guises comes with responsibility, and they identify and define four principles that collectively uphold researchers’ intellectual responsibility: truthfulness, justice and fairness, anti-racism, and public beneficence. Researchers should bring their practices into alignment with these principles, and to aid this, the authors name three common ways research practices infringe these principles, suggest a step-by-step process for aligning research choices with the principles, provide rules of thumb for achieving alignment, and give a worked case. The essay concludes by identifying support needed by researchers to act in accord with the proposed framework.



    Upload a copy of this work     Papers currently archived: 89,330

External links

Setup an account with your affiliations in order to access resources via your University's proxy server

Through your library

Similar books and articles

Ethical Tensions in Genetic Counselling Research.Mary-Anne Young - 2011 - Monash Bioethics Review 29 (3):21-42.
An ethical framework for genetic counseling in the genomic era.Leila Jamal, Will Schupmann & Benjamin E. Berkman - 2021 - In I. Glenn Cohen, Nita A. Farahany, Henry T. Greely & Carmel Shachar (eds.), Consumer genetic technologies: ethical and legal considerations. Cambridge University Press.
The nature and significance of behavioural genetic information.Ainsley Newson - 2004 - Theoretical Medicine and Bioethics 25 (2):89-111.


Added to PP

12 (#916,829)

6 months
11 (#125,032)

Historical graph of downloads
How can I increase my downloads?

Author Profiles

Citations of this work

No citations found.

Add more citations

References found in this work

No references found.

Add more references