Common and Specific Alterations of Amygdala Subregions in Major Depressive Disorder With and Without Anxiety: A Combined Structural and Resting-State Functional MRI Study
Yao Yao Li, Xiao Kang Ni, Ya Feng You, Yan hua Qing, Pei Rong Wang, Jia shu Yao, Ke Ming Ren, Lei Zhang, Zhi wei Liu, Tie jun Song, Jinhui Wang, Yu-Feng Zang, Yue di Shen & Wei Chen
Frontiers in Human Neuroscience 15 (2021)
AbstractAnxious major depressive disorder is a common subtype of major depressive disorder; however, its unique neural mechanism is not well-understood currently. Using multimodal MRI data, this study examined common and specific alterations of amygdala subregions between patients with and without anxiety. No alterations were observed in the gray matter volume or intra-region functional integration in either patient group. Compared with the controls, both patient groups showed decreased functional connectivity between the left superficial amygdala and the left putamen, and between the right superficial amygdala and the bilateral anterior cingulate cortex and medial orbitofrontal cortex, while only patients with anxiety exhibited decreased activity in the bilateral laterobasal and superficial amygdala. Moreover, the decreased activity correlated negatively with the Hamilton depression scale scores in the patients with anxiety. These findings provided insights into the pathophysiologic processes of anxious major depressive disorder and may help to develop new and effective treatment programs.
Similar books and articles
Increased Amygdala-Paracentral Lobule/Precuneus Functional Connectivity Associated With Patients With Mood Disorder and Suicidal Behavior.Ran Zhang, Luheng Zhang, Shengnan Wei, Pengshuo Wang, Xiaowei Jiang, Yanqing Tang & Fei Wang - 2021 - Frontiers in Human Neuroscience 14.
Long-Term Neuroanatomical Consequences of Childhood Maltreatment: Reduced Amygdala Inhibition by Medial Prefrontal Cortex.Roman Kessler, Simon Schmitt, Torsten Sauder, Frederike Stein, Dilara Yüksel, Dominik Grotegerd, Udo Dannlowski, Tim Hahn, Astrid Dempfle, Jens Sommer, Olaf Steinsträter, Igor Nenadic, Tilo Kircher & Andreas Jansen - 2020 - Frontiers in Neuroscience 2020.
Aberrant Gray Matter Networks in Non-Comorbid Medication-Naive Patients With Major Depressive Disorder and Those With Social Anxiety Disorder.Youjin Zhao, Running Niu, Chandan du LeiShah, Yuan Xiao, Wenjing Zhang, Ziqi Chen, Su Lui & Qiyong Gong - 2020 - Frontiers in Human Neuroscience 14.
Three-Dimensional Components of Selfhood in Treatment-Naive Patients with Major Depressive Disorder: A Resting-State qEEG Imaging Study.Andrew A. Fingelkurts & Alexander A. Fingelkurts - 2017 - Neuropsychologia 99:30-36.
Power Laws in Covariability of Anxiety and Depression Among Newly Diagnosed Patients with Major Depressive Episode, Panic Disorder and Controls.David A. Katerndahl - 2009 - Journal of Evaluation in Clinical Practice 15 (3):565-570.
Into the Dark Room: A Predictive Processing Account of Major Depressive Disorder.Regina E. Fabry - 2020 - Phenomenology and the Cognitive Sciences 19 (4):685-704.
Abnormal Whole Brain Functional Connectivity Pattern Homogeneity and Couplings in Migraine Without Aura.Yingxia Zhang, Hong Chen, Min Zeng, Junwei He, Guiqiang Qi, Shaojin Zhang & Rongbo Liu - 2020 - Frontiers in Human Neuroscience 14.
Individual Differences in Amygdala and Ventromedial Prefrontal Cortex Activity Are Associated with Evaluation Speed and Psychological Well-Being.Corrina J. Frye, Hillary S. Schaefer & Andrew L. Alexander - unknown
Anterior Cingulate Cortex-Related Connectivity in First-Episode Schizophrenia: A Spectral Dynamic Causal Modeling Study with Functional Magnetic Resonance Imaging.Long-Biao Cui, Jian Liu, Liu-Xian Wang, Chen Li, Yi-Bin Xi, Fan Guo, Hua-Ning Wang, Lin-Chuan Zhang, Wen-Ming Liu, Hong He, Ping Tian, Hong Yin & Hongbing Lu - 2015 - Frontiers in Human Neuroscience 9.
Altered Resting-State Functional Connectivity in Cortical Networks in Psychopathy.Carissa L. Philippi, Maia S. Pujara, Julian C. Motzkin, Joseph P. Newman, Kent A. Kiehl & Michael Koenigs - 2015 - The Journal of Neuroscience 35 (15):6068 – 6078.
Dsm-Iv Hypochondriasis in Primary Care.J. I. Escobar, M. Gara, H. Waitzkin, R. C. Silver, A. Holman & W. Compton - unknown
Altered Dynamic Amplitude of Low-Frequency Fluctuations in Patients With Migraine Without Aura.Hong Chen, Guiqiang Qi, Yingxia Zhang, Ying Huang, Shaojin Zhang, Dongjun Yang, Junwei He, Lan Mu, Lin Zhou & Min Zeng - 2021 - Frontiers in Human Neuroscience 15.
The Cognitive Neuroscience of Psychopathy and Implications for Judgments of Responsibility.R. James R. Blair - 2008 - Neuroethics 1 (3):149-157.
The Amygdala and Ventromedial Prefrontal Cortex: Functional Contributions and Dysfunction in Psychopathy.R. J. Blair - 2008 - Philosophical Transactions of the Royal Society B 363:2557–2565.
Processing of Emotional Information in Major Depressive Disorder: Toward a Dimensional Understanding.Katharina Kircanski & Ian H. Gotlib - 2015 - Emotion Review 7 (3):256-264.
Added to PP
Historical graph of downloads
Citations of this work
Volume of Amygdala Subregions and Clinical Manifestations in Patients With First-Episode, Drug-Naïve Major Depression.Hirofumi Tesen, Keita Watanabe, Naomichi Okamoto, Atsuko Ikenouchi, Ryohei Igata, Yuki Konishi, Shingo Kakeda & Reiji Yoshimura - 2022 - Frontiers in Human Neuroscience 15.