Cell Fate and Developmental Regulation Dynamics by Polycomb Proteins and 3D Genome Architecture

Bioessays 41 (3):1800222 (2019)

Abstract
Targeted transitions in chromatin states at thousands of genes are essential drivers of eukaryotic development. Therefore, understanding the in vivo dynamics of epigenetic regulators is crucial for deciphering the mechanisms underpinning cell fate decisions. This review illustrates how, in addition to its cell memory function, the Polycomb group of transcriptional regulators orchestrates temporal, cell and tissue‐specific expression of master genes during development. These highly sophisticated developmental transitions are dependent on the context‐ and tissue‐specific assembly of the different types of Polycomb Group (PcG) complexes, which regulates their targeting and/or activities on chromatin. Here, an overview is provided of how PcG complexes function at multiple scales to regulate transcription, local chromatin environment, and higher order structures that support normal differentiation and are perturbed in tumorigenesis.
Keywords 3D genome  Polycomb  chromatin
Categories (categorize this paper)
DOI 10.1002/bies.201800222
Options
Edit this record
Mark as duplicate
Export citation
Find it on Scholar
Request removal from index
Revision history

Download options

Our Archive


Upload a copy of this paper     Check publisher's policy     Papers currently archived: 46,179
External links

Setup an account with your affiliations in order to access resources via your University's proxy server
Configure custom proxy (use this if your affiliation does not provide a proxy)
Through your library

References found in this work BETA

No references found.

Add more references

Citations of this work BETA

No citations found.

Add more citations

Similar books and articles

The Genome as a Developmental Organ.Ehud Lamm - 2014 - Journal of Physiology 592 (11):2237-2244.

Analytics

Added to PP index
2019-02-22

Total views
7 ( #932,524 of 2,285,619 )

Recent downloads (6 months)
4 ( #324,448 of 2,285,619 )

How can I increase my downloads?

Downloads

My notes

Sign in to use this feature