Classic Psychedelics in Translational Research: Addressing Epistemic Challenges from Bench to Bedside

In Chris Letheby & Philip Gerrans (eds.), Philosophical Perspectives on Psychedelic Psychiatry. Oxford University Press (forthcoming)
  Copy   BIBTEX

Abstract

In the last decade alone, a growing body of preliminary evidence suggests that classic psychedelics (CPs) can rapidly and durably ameliorate symptoms and cognitive deficits associated with depression. However, the mechanisms by which CPs work in the brain are not well understood. Rodent translational research, in which experimental findings from rodents are translated to humans, is fundamental in achieving this goal. This chapter focuses on a representative subset of human and rodent studies investigating CPs for depression, including the various lines of research that have been initiated to understand how they work. Our aim is to show that in addition to epistemic challenges that scientists face in translating findings from rodents to humans, there is also mismatch between experimental approaches used to investigate CPs in humans and rodents. We thus show current experimental practices are not conducive to mechanistic discovery. We end with a set of positive proposals to expedite the drive to translate CPs into effective treatments for depression. Keywords: classic psychedelics, psychiatry, clinical trials, collaboration, extrapolation, major depressive disorder, open science, philosophy of science, rodent models, scientific practice, translation, validity

Links

PhilArchive

External links

  • This entry has no external links. Add one.
Setup an account with your affiliations in order to access resources via your University's proxy server

Through your library

Similar books and articles

Translating Trial Results in Clinical Practice: the Risk GP Model.Jonathan Fuller & Luis J. Flores - 2016 - Journal of Cardiovascular Translational Research 9:167-168.
Expanding the Role of Bioethics in Translational Science.Mark A. Rothstein - 2022 - Journal of Law, Medicine and Ethics 50 (3):603-607.
Culture, Context, and Community in Contemporary Psychedelic Research.Brian D. Earp & David B. Yaden - 2021 - Philosophy, Psychiatry, and Psychology 28 (3):217-221.

Analytics

Added to PP
2023-12-08

Downloads
124 (#149,213)

6 months
102 (#46,660)

Historical graph of downloads
How can I increase my downloads?

Author Profiles

Jaipreet Mattu
University of Western Ontario
Jacqueline Anne Sullivan
University of Western Ontario

Citations of this work

No citations found.

Add more citations

References found in this work

No references found.

Add more references