To Know or Not to Know - Ethical Issues Related to Early Diagnosis of Alzheimer's Disease

Abstract
In Alzheimer's disease (AD), pathological processes start in the brain long before clinical dementia. Biomarkers reflecting brain alterations may therefore indicate disease at an early stage, enabling early diagnosis. This raises several ethical questions and the potential benefits of early diagnosis must be weighted against possible disadvantages. Currently, there are few strong arguments favouring early diagnosis, due to the lack of disease modifying therapy. Also, available diagnostic methods risk erroneous classifications, with potentially grave consequences. However, a possible benefit of early diagnosis even without disease modifying therapy is that it may enable early decision making when patients still have full decision competence, avoiding problems of hypothetical consents. It may also help identifying patients with cognitive dysfunction secondary to other diseases that may be responsive to treatment already today.
Keywords No keywords specified (fix it)
Categories (categorize this paper)
Options
 Save to my reading list
Follow the author(s)
Edit this record
My bibliography
Export citation
Find it on Scholar
Mark as duplicate
Request removal from index
Translate to english
Revision history
Download options
Our Archive


Upload a copy of this paper     Check publisher's policy     Papers currently archived: 31,871
External links

Setup an account with your affiliations in order to access resources via your University's proxy server
Configure custom proxy (use this if your affiliation does not provide a proxy)
Through your library
References found in this work BETA

No references found.

Add more references

Citations of this work BETA

Add more citations

Similar books and articles
The Burden of Dementia: A Medical and Research Perspective.Piero Antuono & Jan Beyer - 1999 - Theoretical Medicine and Bioethics 20 (1):3-13.
What is Diagnosis? Some Critical Reflections.Caroline Whitbeck - 1981 - Theoretical Medicine and Bioethics 2 (3):319-329.
The Question Not Asked: The Challenge of Pleiotropic Genetic Tests.Robert Samuel Wachbroit - 1998 - Kennedy Institute of Ethics Journal 8 (2):131-144.
The Disease Status of Catatonia.Irwin Savodnik - 2002 - Behavioral and Brain Sciences 25 (5):590-591.
Causal Reasoning and the Diagnostic Process.Dominick A. Rizzi - 1994 - Theoretical Medicine and Bioethics 15 (3):315-333.
Added to PP index
2013-01-28

Total downloads
19 ( #295,483 of 2,232,007 )

Recent downloads (6 months)
1 ( #445,892 of 2,232,007 )

How can I increase my downloads?

Monthly downloads
My notes
Sign in to use this feature