It Takes Two to Tango: Genotyping and Phenotyping in Genome-Wide Association Studies

Biological Theory 4 (3):294-301 (2009)
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Abstract

In this article we examine the “phenotype” concept in light of recent technological advances in Genome-Wide Association Studies . By observing the technology and its presuppositions, we put forward the thesis that at least in this case genotype and phenotype are effectively coidentifled one by means of the other. We suggest that the coidentiflcation of genotype-phenotype couples in expression-based GWAS also indicates a conceptual dependence, which we call “co-deñnition.” We note that viewing these terms as codeflned runs against possible expectations, viz., that genotypes and phenotypes could ultimately be expressed independently from one another. In addition, the co-definition of genotypes and phenotypes in this context emphasizes the correlative character of both genotypes and phenotypes in GWAS

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Author Profiles

Ohad Nachtomy
Technion, Israel Institute of Technology
Ayelet Shavit
Hebrew University of Jerusalem

Citations of this work

The genotype/phenotype distinction.Richard Lewontin - 2008 - Stanford Encyclopedia of Philosophy.

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