Methodological Strategies in Microbiome Research and their Explanatory Implications

Perspectives on Science 26 (2):239-265 (2018)

Authors
Derek Skillings
University of North Carolina, Greensboro
Abstract
Microbiome research is the analysis of the aggregated molecular components of a defined microbial community.1 Our examination of this field will focus on how causality is assigned in microbiome analyses, and what methodological strategies are used to identify communities or components of those communities as causal contributors to host states. Earlier microbiome research was conducted at a broad scale via bio informatic analyses of environmental samples, then backed up by whole community transfer experiments. These "top-down" findings, in which the whole community is treated as a unit of investigation, indicated that communities might act as causal agents. More recently, as microbiome research has...
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DOI 10.1162/posc_a_00274
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References found in this work BETA

When Mechanistic Models Explain.Carl F. Craver - 2006 - Synthese 153 (3):355-376.
Mechanisms: What Are They Evidence for in Evidence-Based Medicine?Holly Andersen - 2012 - Journal of Evaluation in Clinical Practice 18 (5):992-999.

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