Bioessays 28 (7):726-738 (2006)

Antoine Danchin
University of Hong Kong
Correspondence analysis of 28 proteomes selected to span the entire realm of prokaryotes revealed universal biases in the proteins’ amino acid distribution. Integral Inner Membrane Proteins always form an individual cluster, which can then be used to predict protein localisation in unknown proteomes, independently of the organism’s biotope or kingdom. Orphan proteins are consistently rich in aromatic residues. Another bias is also ubiquitous: the amino acid composition is driven by the GþC content of the first codon position. An unexpected bias is driven, in many proteomes, by the AANbox of the genetic code, suggesting some functional biochemical relationship between asparagine and lysine. Less-significant biases are driven by the rare amino acids, cysteine and tryptophan. Some allow identification of species-specific functions or localisation such as surface or exported proteins. Errors in genome annotations are also revealed by correspondence analysis, making it useful for quality control and correction.
Keywords amino acid composition of proteins  evolution  origin of life  correspondence analysis
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DOI 10.1002/bies.20431
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The Logic of Metabolism and its Fuzzy Consequences.A. Danchin - 2014 - Environmental Microbiology 16 (1):19-28.

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