Azamacrocyclic Ca2+ Sensitive Contrast Agents for MR Imaging


Abstract
Calcium plays an important role in regulating a great variety of neuronal processes, and many efforts are made to generate gadolinium complexes that can act as calcium-dependent MRI contrast agents. A series of gadolinium chelate complexes based on DO3A were developed, bearing phosphonate groups as an additional coordination sites, which is hypothesized to change relaxivity in magnetic resonance experiments dynamically with Ca2+ concentration. Different lengths of the phosphonate side chains are expected to lead to different binding constants of the phosphonate - gadolinium bonds. The latter property can be exploited for fine-tuning the sensitivity of the agent to calcium ion concentration.
Keywords No keywords specified (fix it)
Categories (categorize this paper)
Options
Edit this record
Mark as duplicate
Export citation
Find it on Scholar
Request removal from index
Translate to english
Revision history

Download options

Our Archive


Upload a copy of this paper     Check publisher's policy     Papers currently archived: 41,481
External links

Setup an account with your affiliations in order to access resources via your University's proxy server
Configure custom proxy (use this if your affiliation does not provide a proxy)
Through your library

References found in this work BETA

No references found.

Add more references

Citations of this work BETA

No citations found.

Add more citations

Similar books and articles

The Contrast-Sensitivity of Knowledge Ascriptions.Jonathan Schaffer - 2008 - Social Epistemology 22 (3):235-245.
Empathy, Shared Intentionality, and Motivation by Moral Reasons.Marion Hourdequin - 2012 - Ethical Theory and Moral Practice 15 (3):403 - 419.

Analytics

Added to PP index
2010-12-22

Total views
25 ( #330,994 of 2,248,507 )

Recent downloads (6 months)
1 ( #1,031,786 of 2,248,507 )

How can I increase my downloads?

Downloads

My notes

Sign in to use this feature