Proceedings of the National Academy of Sciences 103 (47):17858--17861 (2006)
The main objective of immunology is to establish why and when an immune response occurs, that is, to determine a criterion of immunogenicity. According to the consensus view, the proper criterion of immunogenicity lies in the discrimination between self and nonself. Here we challenge this consensus by suggesting a simpler and more comprehensive criterion, the criterion of continuity. Moreover, we show that this criterion may be considered as an interpretation of the immune 'self'. We conclude that immunologists can continue to speak of the self, provided that they admit that the self/nonself discrimination is not an adequate criterion of immunogenicity
|Keywords||No keywords specified (fix it)|
|Categories||categorize this paper)|
References found in this work BETA
No references found.
Citations of this work BETA
A Mixed Self: The Role of Symbiosis in Development.Thomas Pradeu - 2011 - Biological Theory 6 (1):80-88.
Plant Individuality: A Solution to the Demographer's Dilemma.Ellen Clarke - 2012 - Biology and Philosophy 27 (3):321-361.
Organisms as Ecosystems/Ecosystems as Organisms.Minus van Baalen & Philippe Huneman - 2014 - Biological Theory 9 (4):357-360.
Breaking with the Self: Can Continuity in Immunology Succeed?Neeraja Sankaran - 2013 - Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences 44 (2):242-246.
Similar books and articles
(C) Instances, the Relevance Criterion, and the Paradoxes of Confirmation.Phillip J. Rody - 1978 - Philosophy of Science 45 (2):289-302.
Epistemic Relativism and the Problem of the Criterion.Howard Sankey - 2011 - Studies in History and Philosophy of Science Part A 42 (4):562-570.
Protecting Human Dignity in Research Involving Humans.Thomas De Koninck - 2009 - Journal of Academic Ethics 7 (1-2):17-25.
The Conservative Use of the Brain-Death Criterion – a Critique.Tom Tomlinson - 1984 - Journal of Medicine and Philosophy 9 (4):377-394.
Ecosystem Sustainability as a Criterion for Genuine Virtue.Louke van Wensveen - 2001 - Environmental Ethics 23 (3):227-241.
An Analysis of the Criteria for Evaluating Adequate Theories of Computation.Nir Fresco - 2008 - Minds and Machines 18 (3):379-401.
Added to index2009-01-28
Total downloads20 ( #244,788 of 2,158,310 )
Recent downloads (6 months)2 ( #194,705 of 2,158,310 )
How can I increase my downloads?