The Philosophical Origins of Mitchell's Chemiosmotic Concepts: The Personal Factor in Scientific Theory Formulation

Journal of the History of Biology 34 (3):433 - 460 (2001)
Abstract
Mitchell's formulation of the chemiosmotic theory of oxidative phosphorylation in 1961 lacked any experimental support for its three central postulates. The path by which Mitchell reached this theory is explored. A major factor was the role of Mitchell's philosophical system conceived in his student days at Cambridge. This system appears to have become a tacit influence on his work in the sense that Polanyi understood all knowledge to be generated by an interaction between tacit and explicit knowing. Early in his life Mitchell had evolved a simple philosophy based on fluctoids, fluctids and statids which was developed in a thesis submitted for the Ph.D. at the University of Cambridge, England. This aspect of his work was rejected by the examiners and became a tacit element in his intellectual development. It is argued from his various publications that this philosophy can be traced as an underlying theme behind much of Mitchell's theoretical writing in the 50's leading, through his notion of vectorial metabolism, to the formulation and amplification of the chemiosmotic theory in the sixties. This philosophy formed the basis for Mitchell of his understanding of biological systems and gave him his unique approach to cell biology.
Keywords bioenergetics  chemiosmotic theory  fluctoids  membrane transport,/kwd>  Peter Mitchell  Michael Polanyi  oxidative phosphorylation  vectorial metabolism
Categories (categorize this paper)
DOI 10.1023/A:1012946715673
Options
 Save to my reading list
Follow the author(s)
My bibliography
Export citation
Find it on Scholar
Edit this record
Mark as duplicate
Revision history
Request removal from index
Download options
Our Archive


Upload a copy of this paper     Check publisher's policy on self-archival     Papers currently archived: 25,071
Through your library
References found in this work BETA

No references found.

Add more references

Citations of this work BETA
Surfaces of Action: Cells and Membranes in Electrochemistry and the Life Sciences.Mathias Grote - 2010 - Studies in History and Philosophy of Science Part C 41 (3):183-193.
Introduction to the Special Issue on Biology and Agriculture.Jonathan Harwood - 2006 - Journal of the History of Biology 39 (2):237 - 239.

View all 7 citations / Add more citations

Similar books and articles
Unsimple Truths: Science, Complexity, and Policy.Sandra D. Mitchell - 2009 - The University of Chicago Press Chicago and London.
Sir William Mitchell and the "New Mysterianism".W. M. Davies - 1999 - Australasian Journal of Philosophy 77 (3):253-73.
Origins of Analytical Philosophy.Mitchell S. Green - 1995 - Philosophical Review 104 (4):613-615.
Faith and Logic.Basil Mitchell (ed.) - 1957 - London: Allen & Unwin.
Self-Expression.S. Green Mitchell - 2007 - Oxford University Press.

Monthly downloads

Added to index

2011-05-29

Total downloads

8 ( #472,536 of 2,132,831 )

Recent downloads (6 months)

1 ( #389,585 of 2,132,831 )

How can I increase my downloads?

My notes
Sign in to use this feature


Discussion
Order:
There  are no threads in this forum
Nothing in this forum yet.

Other forums