GABAA Receptor Deficits Predict Recovery in Patients With Disorders of Consciousness: A Preliminary Multimodal [11C]Flumazenil PET and fMRI Study

Human Brain Mapping:DOI: 10.1002/hbm.22883 (2015)
Authors
Timothy Joseph Lane
Taipei Medical College
Georg Northoff
University of Ottawa
Abstract
Disorders of consciousness (DoC)—that is, unresponsive wakefulness syndrome/vegetative state and minimally conscious state—are debilitating conditions for which no reliable markers of consciousness recovery have yet been identified. Evidence points to the GABAergic system being altered in DoC, making it a potential target as such a marker.
Keywords vegetative state  minimally conscious state  functional connectivity  unresponsive wakefulness syndrome  Zolpidem  salience network  default-mode network  executive-control network
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