Widespread depolarization during expiration: A source of respiratory drive?

Medical Hypotheses 84 (1):31-37 (2014)
  Copy   BIBTEX


Respiration influences various pacemakers and rhythms of the body during inspiration and expiration but the underlying mechanisms are relatively unknown. Understanding this phenomenon is important, as breathing disorders, breath holding, and hyperventilation can lead to significant medical conditions. We discuss the physiological modulation of heart rhythm, blood pressure, sympathetic nerve activity, EEG, and other changes observed during inspiration and expiration. We also correlate the intracellular mitochondrial respiratory metabolic processes with real-time breathing and correlate membrane potential changes with inspiration and expiration. We propose that widespread minor hyperpolarization occurs during inspiration and widespread minor depolarization occurs during expiration. This depolarization is likely a source of respiratory drive. Further knowledge of intracellular and extracellular ionic changes associated with respiration will enhance our understanding of respiration and its role as a modulator of cellular membrane potential. This could expand treatment options for a wide range of health conditions, such as breathing disorders, stress-related disorders, and further our understanding of the Hering–Breuer reflex and respiratory sinus arrhythmia.



External links

  • This entry has no external links. Add one.
Setup an account with your affiliations in order to access resources via your University's proxy server

Through your library

Similar books and articles

The Inspiration-Expiration Ratio During Truth and Falsehood.H. E. Burtt - 1921 - Journal of Experimental Psychology 4 (1):1.
A Simple Device for Recording Inspiration-Expiration Time.H. K. Nixon - 1923 - Journal of Experimental Psychology 6 (5):383.
Further Technique for Inspiration-Expiration Ratios.H. E. Burtt - 1921 - Journal of Experimental Psychology 4 (2):106.
The Relation of Reaction-Time to Phase of Breathing.H. V. Gaskill - 1928 - Journal of Experimental Psychology 11 (5):364.
Augmentation of Mind-Body Therapy and Role of Deep Slow Breathing.Jerath Ravinder & Vernon A. Barnes - 2009 - Journal of Complementary and Integrative Medicine 1:1-7.
A Study of Conditioned Respiratory Changes.C. R. Garvey - 1933 - Journal of Experimental Psychology 16 (4):471.
The Agony of Agonal Respiration: Is the Last Gasp Necessary?R. M. Perkin - 2002 - Journal of Medical Ethics 28 (3):164-169.
The Expiration of Morality.Wallace I. Matson - 1994 - Social Philosophy and Policy 11 (1):159-178.


Added to PP

528 (#18,057)

6 months
30 (#35,274)

Historical graph of downloads
How can I increase my downloads?

Author's Profile

References found in this work

No references found.

Add more references