Mutated mtDNA distribution in exponentially growing cell cultures and how the segregation rate is increased by the mitochondrial compartments
Acta Biotheoretica 49 (4):235-245 (2001)
A cell contains many copies of mitochondrial DNA. The distribution of a mitochondrial gene mutation in a cell culture is governed by the way in which the mtDNA molecules of a cell are replicated and partitioned between the two daughter cells during mitosis. Assuming that this partition process is random, we describe the evolution of the mitochondrial genetic state of a cell culture. The mutated mtDNA is ultimately segregated and the rate of the trend to segregation is relatively slow. It is nevertheless greatly accelerated if the model takes into account the spatial mtDNA partition by the mitochondrial compartments.
|Keywords||Philosophy Philosophy of Biology Evolutionary Biology|
|Categories||categorize this paper)|
References found in this work BETA
No references found.
Citations of this work BETA
No citations found.
Similar books and articles
Response to “Germ Line Therapy to Cure Mitochondrial Disease: Protocol and Ethics of In Vitro Ovum Nuclear Transplantation” by Donald S. Rubenstein, David C. Thomasma, Eric A. Schon, and Michael J. Zinaman (CQ Vol 4, No 3) Altering the Mitochondrial Genome: Is It Just a Technical Issue? [REVIEW]Imre Szebik - 1999 - Cambridge Quarterly of Healthcare Ethics 8 (3):369-374.
A Stochastic Model of Cell Replicative Senescence Based on Telomere Shortening, Oxidative Stress, and Somatic Mutations in Nuclear and Mitochondrial DNA.Peter D. Sozou & Thomas B. L. Kirkwood - unknown
Measurement of Efflux From G1-Phase in a Growth Factor Dependent Cell Line.Joachim W. Ellwart & Peter Dörmer - 1992 - Acta Biotheoretica 40 (2-3):139-146.
Transmission of Mechanical Stresses Within the Cytoskeleton of Adherent Cells: A Theoretical Analysis Based on a Multi-Component Cell Model.Philippe Tracqui & Jacques Ohayon - 2004 - Acta Biotheoretica 52 (4):323-341.
Dynamic Simulation of Mitochondrial Respiration and Oxidative Phosphorylation: Comparison with Experimental Results.François Guillaud & Patrick Hannaert - 2008 - Acta Biotheoretica 56 (1-2):157-172.
Social Experiments in Stem Cell Biology.Melinda B. Fagan - 2011 - Perspectives on Science 19 (3):235-262.
Interventions in the Human Genome: Some Moral and Ethical Considerations.Gerd Richter & Matthew D. Bacchetta - 1998 - Journal of Medicine and Philosophy 23 (3):303 – 317.
Added to index2009-01-28
Total downloads5 ( #600,892 of 2,171,820 )
Recent downloads (6 months)1 ( #326,616 of 2,171,820 )
How can I increase my downloads?