Philosophy of Science 85 (5):1078-1089 (2018)

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Sarah Robins
University of Kansas
Abstract
Optogenetics makes possible the control of neural activity with light. In this paper, I explore how the development of this experimental tool has brought about methodological and theoretical advances in the neurobiological study of memory. I begin with Semon's distinction between the engram and the ecphory, explaining how these concepts present a methodological challenge to investigating memory. Optogenetics provides a way to intervene into the engram without the ecphory that, in turn, opens up new means for testing theories of memory error. I focus on a series of experiments where optogenetics is used to study false memory and forgetting.
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DOI 10.1086/699692
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