Exploring the Ethics of Tuberculosis Human Challenge Models
Abstract
TB human challenge studies could accelerate TB vaccine development by reducing uncertainty in early-stage vaccine testing, selecting promising vaccine candidates for large-scale field trials, and identifying an immune correlate of protection. However, ethical concerns regarding the exposure of trial participants and bystanders to significant risk have been a limiting factor for TB human challenge models. We analyze the expected social value and risks of different types of TB human challenge models, and conclude that given the massive public health burden of TB, challenge models with even scant probabilities of expediting TB vaccine authorization have enormous expected humanitarian value, saving between 33,000 and 1,375,000 lives over the next ten years. We argue that attenuated M.tb challenge trials can be conducted ethically, and discuss the benefits and drawbacks of conducting virulent M.tb challenge trials.Author Profiles
My notes
Similar books and articles
The Ethics of Human Challenge Trials Using Emerging SARS-CoV-2 Virus Variants.Abie Rohrig & Nir Eyal - manuscript
Ethical Considerations for International Recruitment in COVID-19 Human Challenge Trials.Kaleem Ahmid, Abie Rohrig, Paul Ndebele, Zacharia Kafuko & Josh Morrison - manuscript
Ethical aspects of directly observed treatment for tuberculosis: a cross-cultural comparison. [REVIEW]Mette Sagbakken, Jan C. Frich, Gunnar A. Bjune & John D. H. Porter - 2013 - BMC Medical Ethics 14 (1):25.
Pandemic ethics: the case for risky research.Richard Yetter Chappell & Peter Singer - 2020 - Research Ethics 16 (3-4):1-8.
Ethics, Tuberculosis, and Compassion: Lessons From Praxis: Comment on “The Ethics of Isolation for Patients With Tuberculosis in Australia”.Justin Denholm - 2016 - Journal of Bioethical Inquiry 13 (1):161-162.
COVID-19 human challenge trials – what research ethics committees need to consider.Lisa Tambornino & Dirk Lanzerath - 2020 - Research Ethics 16 (3-4):1-11.
Challenge studies of human volunteers: ethical issues.T. Hope - 2004 - Journal of Medical Ethics 30 (1):110-116.
What risks should be permissible in controlled human infection model studies?Ariella Binik - 2020 - Bioethics 34 (4):420-430.
Rebuilding the Public Health Infrastructure: The Challenge of Tuberculosis Control in New York City.Margaret A. Hamburg - 1993 - Journal of Law, Medicine and Ethics 21 (3-4):352-359.
Rebuilding the Public Health Infrastructure: The Challenge of Tuberculosis Control in New York City.Margaret A. Hamburg - 1993 - Journal of Law, Medicine and Ethics 21 (3-4):352-359.
Ethics, tuberculosis and globalization.Michael J. Selgelid - 2008 - Public Health Ethics 1 (1):10-20.
Judging the social value of controlled human infection studies.Annette Rid & Meta Roestenberg - 2020 - Bioethics 34 (8):749-763.
The Political and Ethical Challenge of Multi-Drug Resistant Tuberculosis.Ross Upshur, Ian Kerridge, Wendy Lipworth, Christopher Mayes & Chris Degeling - 2015 - Journal of Bioethical Inquiry 12 (1):107-113.
Convergent ethical issues in HIV/AIDS, tuberculosis and malaria vaccine trials in Africa: Report from the WHO/UNAIDS African AIDS Vaccine Programme's Ethics, Law and Human Rights Collaborating Centre consultation, 10-11 February 2009, Durban, South Africa. [REVIEW]Nicole Mamotte, Douglas Wassenaar, Jennifer Koen & Zaynab Essack - 2010 - BMC Medical Ethics 11 (1):3-.
Analytics
Added to PP
2021-10-21
Downloads
252 (#49,013)
6 months
69 (#16,309)
2021-10-21
Downloads
252 (#49,013)
6 months
69 (#16,309)
Historical graph of downloads
Author Profiles
References found in this work
Pandemic ethics: the case for risky research.Richard Yetter Chappell & Peter Singer - 2020 - Research Ethics 16 (3-4):1-8.