Abstract

There is increasing evidence that carbohydrate antigens act as cell recognition molecules in the highly organized structure of the nervous system. These carbohydrate antigens may be expressed as glycolipids, glycoproteins or proteoglycans, and in some cases all three forms of these glycoconjugates, expressing identical carbohydrate epitopes, can be detected in a specific brain region. This article summarizes recent studies concerning the expression of glycoconjugates during development of the vertebrate central nervous system. These findings are discussed in association with current models of glycoconjugate function.