Authors
Kenneth Schaffner
University of Pittsburgh
Abstract
This article examines how a molecular "solution" to an important biological problem-how is antibody diversity generated? was obtained in the 1970s. After the primarily biological clonal selection theory (CST) was accepted by 1967, immunologists developed several different contrasting theories to complete the SCST. To choose among these theories, immunology had to turn to the new molecular biology, first to nucleic acid hybridization and then to recombinant DNA technology. The research programs of Tonegawa and Leder that led to the "solution" are discussed, and some of their strategies and heuristics are broadly characterized: (1) to what extent does the new recombinant DNA technology provide what the scientists claim is "direct evidence," what does that term mean, and what are the implications of that claim for biological "realism," and (2) is this episode one of reduction, partial reduction, or explanatory extension, and what do these terms mean in the context of a successful molecular "solution" to a biological problem.
Keywords No keywords specified (fix it)
Categories (categorize this paper)
Options
Edit this record
Mark as duplicate
Export citation
Find it on Scholar
Request removal from index
Revision history

Download options

PhilArchive copy


Upload a copy of this paper     Check publisher's policy     Papers currently archived: 60,021
External links

Setup an account with your affiliations in order to access resources via your University's proxy server
Configure custom proxy (use this if your affiliation does not provide a proxy)
Through your library

References found in this work BETA

No references found.

Add more references

Citations of this work BETA

On the Genesis of the Idiotypic Network Theory.Andrea Civello - 2013 - Journal of the History of Biology 46 (1):125-158.

Add more citations

Similar books and articles

Mechanism Schemas and the Relationship Between Biological Theories.Tudor M. Baetu - 2011 - In Phyllis McKay Illari Federica Russo (ed.), Causality in the Sciences. Oxford University Press.
Molecular Biology and the Unity of Science.Harold Kincaid - 1990 - Philosophy of Science 57 (4):575-593.
The Adaptive Radiation of Biological Explanation.Niall Shanks - 2001 - Idealistic Studies 31 (2/3):155-168.
Naturalists, Molecular Biologists, and the Challenges of Molecular Evolution.Joel B. Hagen - 1999 - Journal of the History of Biology 32 (2):321 - 341.
Is the Neo-Darwinian Synthesis Robust Enough to Withstand the Challenge of Recent Discoveries in Molecular Biology and Molecular Evolution?John R. Jungck - 1982 - PSA: Proceedings of the Biennial Meeting of the Philosophy of Science Association 1982:322 - 328.
Crick's Notion of Genetic Information and the ‘Central Dogma’ of Molecular Biology.Predrag Šustar - 2007 - British Journal for the Philosophy of Science 58 (1):13-24.
Theory Structure and Theory Change in Contemporary Molecular Biology.Sylvia Culp & Philip Kitcher - 1989 - British Journal for the Philosophy of Science 40 (4):459-483.

Analytics

Added to PP index
2011-05-29

Total views
22 ( #482,197 of 2,433,467 )

Recent downloads (6 months)
1 ( #468,801 of 2,433,467 )

How can I increase my downloads?

Downloads

My notes