How Acts of Infidelity Promote DNA Break Repair: Collision and Collusion Between DNA Repair and Transcription

Bioessays 40 (10):1800045 (2018)

Abstract
Transcription is a fundamental cellular process and the first step in gene regulation. Although RNA polymerase (RNAP) is highly processive, in growing cells the progression of transcription can be hindered by obstacles on the DNA template, such as damaged DNA. The authors recent findings highlight a trade‐off between transcription fidelity and DNA break repair. While a lot of work has focused on the interaction between transcription and nucleotide excision repair, less is known about how transcription influences the repair of DNA breaks. The authors suggest that when the cell experiences stress from DNA breaks, the control of RNAP processivity affects the balance between preserving transcription integrity and DNA repair. Here, how the conflict between transcription and DNA double‐strand break (DSB) repair threatens the integrity of both RNA and DNA are discussed. In reviewing this field, the authors speculate on cellular paradigms where this equilibrium is well sustained, and instances where the maintenance of transcription fidelity is favored over genome stability.
Keywords DNA break repair  DNA resection  RNA polymerase  RecBCD  genome stability  transcription fidelity
Categories (categorize this paper)
DOI 10.1002/bies.201800045
Options
Edit this record
Mark as duplicate
Export citation
Find it on Scholar
Request removal from index
Revision history

Download options

Our Archive


Upload a copy of this paper     Check publisher's policy     Papers currently archived: 39,669
External links

Setup an account with your affiliations in order to access resources via your University's proxy server
Configure custom proxy (use this if your affiliation does not provide a proxy)
Through your library

References found in this work BETA

No references found.

Add more references

Citations of this work BETA

No citations found.

Add more citations

Similar books and articles

DNA Repair: The Search for Homology.James E. Haber - 2018 - Bioessays 40 (5):1700229.
Ruin, Repair, and Responsibility.Bat-Ami Bar On - 2002 - International Journal of Philosophical Studies 10 (2):195 – 207.

Analytics

Added to PP index
2018-08-09

Total views
12 ( #582,025 of 2,326,089 )

Recent downloads (6 months)
9 ( #142,767 of 2,326,089 )

How can I increase my downloads?

Downloads

My notes

Sign in to use this feature