Acta Biotheoretica 50 (4):323-329 (2002)
The schematic concept of levels of causal interaction is applied to the relation between genetics and biology. The strength of classical formal genetics lies in its power to proceed directly from observations on an external phenotype, to inferences concerning the nature and properties of the fundamental genetic factors. Its weakness comes from the fact that by short-circuiting the causal chain leading from genotype to phenotype, it creates a divorce between genetics and biology. It is argued that in order to reestablish an articulation of genetics and the biology of whole organisms, it will be necessary to study in detail the entire causal chain leading from a difference in a genetic factor to a difference in a corresponding phenotypic character. This proposal is illustrated by a consideration of multifactorial diseases, which appear to be due to strong interactions between a moderate number of distinct loci; the frequency of abnormal alleles at any given locus may be surprisingly high.
|Keywords||Philosophy Philosophy of Biology Evolutionary Biology|
|Categories||categorize this paper)|
References found in this work BETA
No references found.
Citations of this work BETA
No citations found.
Similar books and articles
Holism and Reductionism: A View From Genetics.Arthur Zucker - 1981 - Journal of Medicine and Philosophy 6 (2):145-164.
Reduction in Genetics--Biology or Philosophy?David L. Hull - 1972 - Philosophy of Science 39 (4):491-499.
Population Genetics.Roberta L. Millstein & Robert A. Skipper - 2007 - In David L. Hull & Michael Ruse (eds.), The Cambridge Companion to the Philosophy of Biology. Cambridge University Press.
Righteous Modeling: The Competence of Classical Population Genetics. [REVIEW]Peter Gildenhuys - 2011 - Biology and Philosophy 26 (6):813-835.
Exploring the Borderlands: Documents of the Committee on Common Problems of Genetics, Paleontology, and Systematics.Joe Cain (ed.) - 1943 - American Philosophical Society.
Racialized Genetics and the Study of Complex Diseases: The Thrifty Genotype Revisited.Yin Paradies, M. J. Montoya & Stephanie M. Fullerton - 2007 - Perspectives in Biology and Medicine 50 (2):203-227.
Phenotype-Genotype Dichotomy: An Essay in Theoretical Biology.Piotr Lenartowicz - 1975 - Typis Pontificiae Universitatis Gregorianae.
Mechanism Schemas and the Relationship Between Biological Theories.Tudor M. Baetu - 2011 - In Phyllis McKay Illari Federica Russo (ed.), Causality in the Sciences. Oxford University Press.
The Formal Structure of Genetics and the Reduction Problem.A. Lindenmayer & N. Simon - 1980 - PSA: Proceedings of the Biennial Meeting of the Philosophy of Science Association 1980:160 - 170.
On the Reduction of Genetics to Molecular Biology.Steven Orla Kimbrough - 1979 - Philosophy of Science 46 (3):389-406.
Added to index2009-01-28
Total downloads9 ( #466,563 of 2,178,195 )
Recent downloads (6 months)1 ( #316,497 of 2,178,195 )
How can I increase my downloads?