Gate control theory reconsidered

Brain and Mind 3 (2):277-290 (2002)
Abstract
It has been 35 years since the publicationMelzack and Wall's Gate Control Theory whichhypothesized that nociceptive information wassubject to dynamic regulation by mechanismslocated in the spinal cord dorsal horn thatcould ultimately lead to hyperalgesic orhypoalgesic states. This paper examines GateControl Theory in light of our currentunderstanding of the neuroanatomical,neurophysiological and neurochemical substratesof nociception and antinociception. Despiteits initial controversies, no one has proposeda more comprehensive overall theory of painmodulation or has successfully refuted most ofthe basic tenets of this theory.
Keywords antinociception  central sensitization  Gate Control Theory  long-term depression  long-term potentiation  neuroplasticity  nociception  pain
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DOI 10.1023/A:1019996809849
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