17 beta-estradiol synthesis modulates cerebellar dependent motor memory formation in adult male rats


Authors
Jacqueline Anne Sullivan
University of Western Ontario
Abstract
Neurosteroid 17 beta-estradiol (E2) is a steroid synthesized de novo in the nervous system that might influence neuronal activity and behavior. Nevertheless, the impact of E2 on the functioning of those neural systems in which it is slightly synthesized is less questioned. The vestibulo-ocular reflex (VOR) adaptation, may provide an ideal arena for investigating this issue. Indeed, E2 modulates cerebellar parallel fiber-Purkinje cell synaptic plasticity that underlies encoding of VOR adaptation. Moreover, aromatase expression in the cerebellum of adult rodents is maintained at very low levels and localized to Purkinje cells. The significance of age-related maintenance of low levels of aromatase expression in the cerebellum on behavior, however, has yet to be explored. Our aim in this study was to determine whether E2 synthesis exerts an effective and persistent modulation of VOR adaptation in adult male rats. To answer this question, we investigated the acute effect of blocking E2 synthesis on gain increases and decreases in VOR adaptation using an oral dose (2.5 mg/kg) of the aromatase inhibitor Letrozole in peri-pubertal and post-pubertal male rats. We found that Letrozole acutely impaired gain increases and decreases in VOR adaptation without altering basal ocular-motor performance and that these effects were similar in peri-pubertal and post-pubertal rats. Thus, in adult male rats neurosteroid E2 effectively modulates VOR adaptation in both of the periods studied. These findings imply that the adult cerebellum uses E2 synthesis for modulating motor memory formation and suggest that low and extremely localized E2 production may play a role in adaptive phenomena.
Keywords No keywords specified (fix it)
Categories (categorize this paper)
Options
Edit this record
Mark as duplicate
Export citation
Find it on Scholar
Request removal from index
Revision history

Download options

PhilArchive copy


Upload a copy of this paper     Check publisher's policy     Papers currently archived: 63,133
External links

Setup an account with your affiliations in order to access resources via your University's proxy server
Configure custom proxy (use this if your affiliation does not provide a proxy)
Through your library

References found in this work BETA

No references found.

Add more references

Citations of this work BETA

No citations found.

Add more citations

Similar books and articles

Models of the Cerebellum and Motor Learning.James C. Houk, Jay T. Buckingham & Andrew G. Barto - 1996 - Behavioral and Brain Sciences 19 (3):368-383.
Spanning the Levels in Cerebellar Function.Michael A. Arbib - 1996 - Behavioral and Brain Sciences 19 (3):434-435.
Which Cerebellar Cells Contribute to Extracellular cGMP?Lech Kiedrowski - 1996 - Behavioral and Brain Sciences 19 (3):464-465.
Motor Learning and Synaptic Plasticity in the Cerebellum.Richard F. Thompson - 1996 - Behavioral and Brain Sciences 19 (3):475-477.

Analytics

Added to PP index
2018-09-10

Total views
0

Recent downloads (6 months)
0

How can I increase my downloads?

Downloads

Sorry, there are not enough data points to plot this chart.

My notes