Qualitative study of comprehension of heritability in genomics studies among the Yoruba in Nigeria

BMC Medical Ethics 21 (1):1-8 (2020)
  Copy   BIBTEX


Background With growth of genomics research in Africa, concern has arisen about comprehension and adequacy of informed consent given the highly technical terms used in this field. We therefore decided to study whether there are linguistic and cultural concepts used to communicate heritability of characters, traits and diseases in an indigenous African population. Methods We conducted Focus Group Discussions among 115 participants stratified by sex, age and socio-economic status and Key Informant Interviews among 25 stakeholders and Key Opinion Leaders among Yoruba living in Ibadan, Nigeria. We used Atlas-ti v.8.3.17 software to analyze the data, using thematic approach. Results The study participants identified several linguistic and cultural concepts including words, proverbs, and aphorisms that are used to describe heritable characters, traits and diseases in their local dialect. These included words that can be appropriated to describe dominant and recessive traits, variations in penetrance and dilution of strength of heritable characteristics by time and inter-marriage. They also suggested that these traits are transmitted by “blood”, and specific partner’s blood may be stronger than the other regardless of sex. Conclusions Indigenous Yoruba populations have words and linguistic concepts that describe the heritability of characters, traits and diseases which can be appropriated to improve comprehension and adequacy of informed consent in genomics research. Our methods are openly available and can be used by genomic researchers in other African communities.



    Upload a copy of this work     Papers currently archived: 91,122

External links

Setup an account with your affiliations in order to access resources via your University's proxy server

Through your library

Similar books and articles

Is heritability explanatorily useful?Christopher H. Pearson - 2007 - Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences 38 (1):270-288.
Surrogate Motherhood and Yoruba African Culture.Aborisade Olasunkanmi - 2015 - Eubios Journal of Asian and International Bioethics 25 (3):66-68.
Changes in Metaphor Comprehension in Children.Ewa Dryll - 2009 - Polish Psychological Bulletin 40 (4):204-212.


Added to PP

10 (#1,074,276)

6 months
4 (#477,225)

Historical graph of downloads
How can I increase my downloads?