A Review of Scientific Ethics Issues Associated with the Recently Approved Drugs for Alzheimer’s Disease [Book Review]

Science and Engineering Ethics 29 (1):1-18 (2023)
  Copy   BIBTEX


Alzheimer’s disease (AD), the devastating and most prevailing underlying cause for age-associated dementia, has no effective disease-modifying treatment. The last approved drug for the relief of AD symptoms was in 2003. The recent approval of sodium oligomannate (GV-971, 2019) in China and the human antibody aducanumab in the USA (ADUHELM, 2021) therefore represent significant breakthroughs, albeit ones that are fraught with controversy. Here, we explore potential scientific ethics issues associated with GV-971 and aducanumab’s development and approval. While these issues may be belied by socioeconomic and political complexities in the heady business of commercial drug development, they are of fundamental importance to scientific integrity and ultimately, welfare of patients. We posit that the push for approval of both AD drugs based on incomplete research and unconvincing marginal effectiveness is ethically unsound. Regardless of how both these drugs shall perform in the market for the years to come, the scientific ethics issues and potentially questionable research practices should therefore be duly noted and lessons learned.



    Upload a copy of this work     Papers currently archived: 92,197

External links

Setup an account with your affiliations in order to access resources via your University's proxy server

Through your library

Similar books and articles

The burden of dementia: A medical and research perspective.Piero Antuono & Jan Beyer - 1999 - Theoretical Medicine and Bioethics 20 (1):3-13.
Classification of Alzheimer’s Disease Using Traditional Classifiers with Pre-Trained CNN.Husam R. Almadhoun & Samy S. Abu-Naser - 2021 - International Journal of Academic Health and Medical Research (IJAHMR) 5 (4):17-21.
Autonomy, Benevolence, and Alzheimer's Disease.Pam R. Sailors - 2001 - Cambridge Quarterly of Healthcare Ethics 10 (2):184-193.


Added to PP

18 (#836,359)

6 months
6 (#529,161)

Historical graph of downloads
How can I increase my downloads?

Citations of this work

No citations found.

Add more citations

References found in this work

Add more references