The immune system and its ecology

Philosophy of Science 75 (2):224-245 (2008)
In biology, the ‘ecological orientation' rests on a commitment to examining systems, and the conceptual challenge of defining that system now employs techniques and concepts adapted from diverse disciplines (i.e., systems philosophy, cybernetics, information theory, computer science) that are applied to biological simulations and model building. Immunology has joined these efforts, and the question posed here is whether the discipline will remain committed to its theoretical concerns framed by the notions of protecting an insular self, an entity demarcated from its environment, or will shift its focus of interest to a wider context. An ecological perspective emphasizes the interchange between the organism and its environment, the processing of information, and the regulation arising from responses to this larger context. Moving from the first attempts at modeling the immune system as a closed network, immunologists have joined the general interest in systems analysis, and that move might portend a significant shift to an open, more holistic consideration of immune regulation. *Received December 2006; revised August 2007. †To contact the author, please write to: Center for Philosophy and History of Science, Boston University, 745 Commonwealth Ave., Boston, MA 02215; e-mail:
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DOI 10.1086/590200
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References found in this work BETA
The Dialectical Biologist.Richard Levins - 1985 - Harvard University Press.
The Immune Self Theory or Metaphor?Alfred I. Tauber - 1994 - Cambridge University Press.

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Citations of this work BETA
Philosophy as Self-Knowledge.Alfred I. Tauber - 2014 - Philosophia 42 (1):1-23.
Imagining 'Reactivity': Allergy Within the History of Immunology.Michelle Jamieson - 2010 - Studies in History and Philosophy of Science Part C 41 (4):356-366.
Imagining ‘Reactivity’: Allergy Within the History of Immunology.Michelle Jamieson - 2010 - Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences 41 (4):356-366.

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