Abstract
: Nearly all of the literature on the ethical, legal, or social issues surrounding genetic tests has proceeded on the assumption that any particular test for a gene mutation yields information about only one disease condition. Even though the phenomenon of pleiotropy, where a single gene has multiple, apparently unrelated phenotypic effects, is widely recognized in genetics, it has not had much significance for genetic testing until recently. In this article, I examine a moral dilemma created by one sort of pleiotropic testing, APOE genotyping, which can yield information about the risk of two different conditions--coronary heart disease and Alzheimer's disease. A physician administering APOE testing for the beneficial purpose of assessing the risk of heart disease may discover medically useless and socially harmful information about the patient's risk of Alzheimer's disease. I explore how much providers should disclose to patients about pleiotropic test results and whether patients are obligated to know as much about their genetic condition as possible
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DOI 10.1353/ken.1998.0013
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Alzheimer Disease and Pre-Emptive Suicide.Dena S. Davis - 2014 - Journal of Medical Ethics 40 (8):543-549.
Incidental Findings in Genetics Research Using Archived DNA.Ellen Wright Clayton - 2008 - Journal of Law, Medicine and Ethics 36 (2):286-291.
Incidental Findings in Genetics Research Using Archived DNA.Ellen Wright Clayton - 2008 - Journal of Law, Medicine and Ethics 36 (2):286-291.

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