High mental disorder rates are based on invalid measures: Questions about the claimed ubiquity of mutation-induced dysfunction

Behavioral and Brain Sciences 29 (4):424-426 (2006)
Abstract
Three reservations about Keller & Miller's (K&M's) argument are explored: Serious validity problems afflict epidemiological criteria discriminating disorders from non-disorders, so high rates may be misleading. Normal variation need not be mild disorder, contrary to a possible interpretation of K&M's article. And, rather than mutation-selection balance, true disorders may result from unselected combinations of normal variants over many loci. (Published Online November 9 2006).
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DOI 10.1017/S0140525X06429095
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