Placebo-controlled Trials in Schizophrenia: Are They Ethical? Are They Necessary?


Authors
Charles Weijer
University of Western Ontario
Abstract
The current controversy as to the proper role of the placebo control in the evaluation of new treatments for schizophrenia requires an analysis that is sensitive to both ethical and scientific issues. Clinical equipoise, widely regarded as the moral foundation of the randomized controlled trial (RCT), requires the use of best available treatment as the control in RCT. Scientific criticisms of the use of an active control are examined and none present an insuperable barrier to the use of an active control. Indeed, scrutiny of the most recent argument for the use of placebo controls, 'assay sensitivity', suggests that the use of placebo may be the cause of the problem pointed to. Scientific, regulatory, ethical and legal advantages of the use of an active control are described. While the use of a placebo control may be acceptable in carefully defined circumstances, in most cases the use of an active control in schizophrenia research is ethically and scientifically preferable
Keywords No keywords specified (fix it)
Categories (categorize this paper)
Options
Edit this record
Mark as duplicate
Export citation
Find it on Scholar
Request removal from index
Translate to english
Revision history

Download options

Our Archive


Upload a copy of this paper     Check publisher's policy     Papers currently archived: 41,507
External links

Setup an account with your affiliations in order to access resources via your University's proxy server
Configure custom proxy (use this if your affiliation does not provide a proxy)
Through your library

References found in this work BETA

No references found.

Add more references

Citations of this work BETA

The Ethical Analysis of Risk.Charles Weijer - 2000 - Journal of Law, Medicine and Ethics 28 (4):344-361.
When Argument Fails.Charles Weijer - 2002 - American Journal of Bioethics 2 (2):10 – 11.

Add more citations

Similar books and articles

What Makes Placebo-Controlled Trials Unethical?Franklin G. Miller & Howard Brody - 2002 - American Journal of Bioethics 2 (2):3 – 9.
The Necessity and the Value of Placebo.Ernst A. Singer - 2004 - Science and Engineering Ethics 10 (1):51-56.
Placebo and the Helsinki Declaration — What to Do?Bozidar Vrhovac - 2004 - Science and Engineering Ethics 10 (1):81-93.
Placebo Controls and Epistemic Control in Orthodox Medicine.Mark D. Sullivan - 1993 - Journal of Medicine and Philosophy 18 (2):213-231.
‘Placebos’ and the Logic of Placebo Comparison.Andrew Turner - 2012 - Biology and Philosophy 27 (3):419-432.

Analytics

Added to PP index
2010-09-08

Total views
15 ( #530,794 of 2,248,744 )

Recent downloads (6 months)
3 ( #605,972 of 2,248,744 )

How can I increase my downloads?

Downloads

My notes

Sign in to use this feature