Hastings Center Report 35 (5):37-43 (2005)

Abstract
: When children and incapacitated adults are enrolled in research that cannot directly benefit them, they can be exposed to no more than "minimal" risks, according to guidelines accepted around the world. We need a new standard for what "minimal" risks are, howeve--one that recognizes that participating in nonbeneficial research is like participating in a charitable activity. Such a standard appears likely to provide more stringent protections for these vulnerable populations
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DOI 10.1353/hcr.2005.0087
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On the Minimal Risk Threshold in Research With Children.Ariella Binik - 2014 - American Journal of Bioethics 14 (9):3-12.
Vulnerable Populations in Research: The Case of the Seriously Ill.Philip J. Nickel - 2006 - Theoretical Medicine and Bioethics 27 (3):245-264.
Is There an Objective Way to Compare Research Risks?John Rossi & Robert M. Nelson - 2012 - Journal of Medical Ethics 38 (7):423-427.

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