Off-label, off-limits? Parental awareness and attitudes towards off-label use in paediatrics

European Journal of Pediatrics 168:1473-1478 (2009)
  Copy   BIBTEX


Off-label drug use in paediatrics is associated with an increased risk of adverse drug reactions. Any risk-benefit analysis has to be based on value judgments that should include parents' views. However, nothing is known so far about the parents' perspective on this critical issue. Therefore, a quantitative survey with parents of healthy and chronically ill children was carried out (n=94). Knowledge about the practice of off-label use is generally poor in both groups. Surprisingly, this is also true for the parents of children with chronic disease. 9.3% of the parents of chronically ill children and 19.6% of the parents of healthy children would refuse treatment with an off-label drug. Parents who have poor knowledge about the practice of off-label use tend to refuse to volunteer their child for study participation. Therefore, the information of parents on the off-label use of drugs is important to meet ethical standards and to increase the parents’ acceptance of medical studies with children.



    Upload a copy of this work     Papers currently archived: 93,069

External links

  • This entry has no external links. Add one.
Setup an account with your affiliations in order to access resources via your University's proxy server

Through your library

Similar books and articles

Speaking Off Label.Stephen R. Latham - 2010 - Hastings Center Report 40 (6):9-10.


Added to PP


6 months

Historical graph of downloads

Sorry, there are not enough data points to plot this chart.
How can I increase my downloads?

Author's Profile

Citations of this work

Add more citations

References found in this work

No references found.

Add more references