Authors
Manuel Brenner
Goethe University Frankfurt
Abstract
Background and Objective: Current techniques for oral diagnosis require surgical biopsy of lesions, and may fail to detect early malignant change. Non-invasive, sensitive tools providing early detection of oral cancer and a better understanding of malignant change are needed. These studies evaluated in vivo multiphoton excited fluorescence techniques to map epithelial and subepithelial changes through out oral carcinogenesis and serve as an effective diagnostic modality. Study Design/Materials and Methods: In the hamster model, epithelial and subepithelial change was imaged in vivo throughout carcinogenesis. MPM- and histopathology-based diagnoses on a scale of 0 -6 were scored by two prestandardized investigators. Results: Collagen matrix and fibers, cellular infiltrates, blood vessels, and microtumors were clearly visible. MPM agreed with the histopathology for 88.6% of diagnoses. Conclusions: In vivo MPM images provide high resolution information on specific components of the carcinogenesis process an excellent basis for oral diagnostics. © 2004 Wiley-Liss, Inc.
Keywords No keywords specified (fix it)
Categories No categories specified
(categorize this paper)
Options
Edit this record
Mark as duplicate
Export citation
Find it on Scholar
Request removal from index
Revision history

Download options

PhilArchive copy


Upload a copy of this paper     Check publisher's policy     Papers currently archived: 65,683
External links

Setup an account with your affiliations in order to access resources via your University's proxy server
Configure custom proxy (use this if your affiliation does not provide a proxy)
Through your library

References found in this work BETA

No references found.

Add more references

Citations of this work BETA

No citations found.

Add more citations

Similar books and articles

Analytics

Added to PP index
2017-05-07

Total views
1 ( #1,516,202 of 2,462,377 )

Recent downloads (6 months)
1 ( #449,313 of 2,462,377 )

How can I increase my downloads?

Downloads

Sorry, there are not enough data points to plot this chart.

My notes