Intraoperative Liposomal Bupivacaine Does Not Reduce Opioid Use vs. Ropivacaine: A Systematic Review

Journal of Surgery 7 (1570) (2022)
  Copy   BIBTEX

Abstract

Introduction: Liposomal bupivacaine (LB) is a long-acting analgesic that, due to its liposomal formulation, purportedly extends its analgesic effect up to 72 hours. However, the clinical efficacy of LB appears mixed. This systematic review seeks to evaluate the effectiveness of liposomal bupivacaine in improving postoperative outcomes compared to ropivacaine (ROPI), another commonly used long-acting analgesic. Materials and Methods: Prospective and randomized controlled trials (RCTs) evaluating the efficacy of LB compared to ROPI were selected for review. Primary outcomes included hospital length of stay (LOS) and postoperative opioid consumption measured in oral morphine equivalents (OME). Secondary outcomes included analgesic cost. Results: 14 studies met the review criteria. We found that LB and ROPI are equivalent in managing postoperative pain. 8 of the 14 trials reported equal efficacy between LB and ROPI as determined by OME post-procedure and 10 of the 14 trials reported similar LOS after surgery. These findings remained consistent across multiple surgical procedures and multiple drug administrative modalities. Conclusion: Our systematic review found that LB was not superior to ROPI in reducing postoperative OME use and hospital LOS. The only consistent finding was the significantly increased cost of LB compared to that of ROPI. Therefore, the use of LB over ROPI cannot be justified.

Other Versions

No versions found

Links

PhilArchive

External links

Setup an account with your affiliations in order to access resources via your University's proxy server

Through your library

Similar books and articles

On the logic of conscious belief.Marek Tokarz - 1990 - Studia Logica 49 (3):321 - 332.
lb. RIGHTS.What Was Self-Evident Alas - 2009 - In Matt Zwolinski (ed.), Arguing About Political Philosophy. London: Routledge. pp. 123.
Studi su LB Alberti'.C. Grayson - forthcoming - Rinascimento.
LB Puntel, Sein und Gott.Erik Meganck - 2012 - Tijdschrift Voor Filosofie 74 (2):410-411.

Analytics

Added to PP
2023-04-03

Downloads
243 (#96,257)

6 months
111 (#48,672)

Historical graph of downloads
How can I increase my downloads?

Author's Profile

Violet Victoria
University of Oklahoma

Citations of this work

No citations found.

Add more citations

References found in this work

No references found.

Add more references